Grantee Research Project Results
Publications Details for Grant Number R835738C004
Organotypic Model of Testis as a Platform for Adverse Outcomes Pathway Assessment of Engineered Nanomaterials
RFA:
Organotypic Culture Models for Predictive Toxicology Center (2013)
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| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Abstract | Faustman EM. Testicular cells co-culture as an alternative model for male reproductive toxicity. The Toxicologist 2017;151(1):144 (Abstract 1613). |
R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
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| Abstract | Shaffer, RM, Wilder CS, Ryu SY, Park JL, Hong S, White CC, Workman T, Griffith WC, Faustman EM. Lifestage-specific modeling platform for adverse outcome pathways of male reproductive and developmental processes. The Toxicologist 2017;151(1):420 (Abstract 2786). |
R835738 (2017) R835738C004 (2017) |
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| Journal Article | Harris S, Hermsen SA, Yu X, Hong SW, Faustman EM. Comparison of toxicogenomic responses to phthalate ester exposure in an organotypic testis co-culture model and responses observed in vivo. Reproductive Toxicology 2015;58:149-159. |
R834514 (Final) R834514C003 (2015) R834514C003 (Final) R835738 (2016) R835738 (2017) R835738C004 (2015) R835738C004 (2017) |
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| Journal Article | Harris S, Wegner S, Hong SW, Faustman EM. Phthalate metabolism and kinetics in an in vitro model of testis development. Toxicology in Vitro 2016;32:123-131. |
R833772 (2009) R834514 (Final) R834514C003 (Final) R835738 (2016) R835738 (2017) R835738C004 (2015) R835738C004 (2016) R835738C004 (2017) |
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| Journal Article | Harris S, Shubin SP, Wegner S, Van Ness K, Green F, Hong SW, Faustman EM. The presence of macrophages and inflammatory responses in an in vitro testicular co-culture model of male reproductive development enhance relevance to in vivo conditions. Toxicology In Vitro 2016;36:210-215. |
R834514 (Final) R834514C003 (Final) R835738 (2016) R835738 (2017) R835738C004 (2016) R835738C004 (2017) |
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| Journal Article | Kim YH, Jo MS, Kim JK, Shin JH, Baek JE, Park HS, An HJ, Lee JS, Kim BW, Kim HP, Ahn KH, Jeon KS, Oh SM, Lee JH, Workman T, Faustman EM, Yu IJ. Short-term inhalation study of graphene oxide nanoplates. Nanotoxicology 2018;12(3):224-238. |
R835738 (2017) R835738C001 (2018) R835738C004 (2018) R835738C005 (2018) |
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| Journal Article | Lee JH, Sung JH, Ryu HR, Song KS, Song NW, Park HM, Shin BS, Ahn K, Gulumian M, Faustman EM, Yu IJ. Tissue distribution of gold and silver after subacute intravenous injection of co-administered gold and silver nanoparticles of similar sizes. Archives of Toxicology 2018;92(4):1393-1405. |
R835738 (2017) R835738C004 (2018) |
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| Journal Article | Melnikov F, Botta D, White CC, Schmuck SC, Schaupp CM, Gallagher EP, Brooks BW, Williams ES, Coish P, Anastas PT, Voutchkova-Kostal A, Kostal J and Kavanagh TJ. Kinetics of Glutathione Depletion and Antioxidant Gene Expression as Indicators of Chemical Modes of Action Assessed in vitro in Mouse Hepatocytes with Enhanced Glutathione Synthesis. Chemical Research in Toxicology2019:32(3);421-436 |
R835738C001 (2018) R835738C003 (2018) R835738C004 (2018) |
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| Journal Article | Park JJ, Weldon BA, Hong S, Workman T, Griffith WC, Park JH, Faustman EM. Characterization of 3D embryonic C57BL/6 and A/J mouse midbrain micromass in vitro culture systems for developmental neurotoxicity testing. Toxicology In Vitro 2018;48:33-44. |
R835738 (2017) R835738C001 (2018) R835738C004 (2018) R835738C005 (2018) |
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| Journal Article | Shaffer R, Smith MN, Faustman EM. Developing the regulatory utility of the exposome: mapping exposures for risk assessment through Lifestage Exposome Snapshots (LEnS). Environmental Health Perspectives 2017;123(8):085003 (8 pp.). |
R835738 (2017) R835738C004 (2018) R835738C005 (2017) |
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| Journal Article | Van Ness KP, Chang SY, Weber EJ, Zumpano D, Eaton DL, Kelly EJ. Microphysiological systems to assess nonclinical toxicity. Current Protocols in Toxicology 2017;73(1):14.18.1-14.18.28. |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) R835738C002 (2018) R835738C004 (2018) R835738C005 (2017) |
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| Journal Article | Wegner SH, Yu X, Pacheco Shubin S, Griffith WC, Faustman EM. Stage-specific signaling pathways during murine testis development and spermatogenesis: a pathway-based analysis to quantify developmental dynamics. Reproductive Toxicology 2015;51:31-39. |
R834514 (2015) R834514 (Final) R834514C003 (2015) R834514C003 (Final) R835738 (2016) R835738 (2017) R835738C004 (2015) R835738C004 (2017) |
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| Journal Article | Weldon BA, Park JJ, Hong S, Workman T, Dills R, Lee JH, Griffith WC, Kavanagh TJ, Faustman EM. Using primary organotypic mouse midbrain cultures to examine developmental neurotoxicity of silver nanoparticles across two genetic strains. Toxicology and Applied Pharmacology 2018:354;215-224 |
R835738 (2017) R835738C004 (2017) R835738C004 (2018) R835738C005 (2017) R835738C005 (2018) |
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| Journal Article | Lee JH, Sung JH, Ryu HR, Song KS, Song NW, Park HM, Shin BS, Ahn K, Gulumian M, Faustman EM, Yu IJ. Tissue Distribution of Gold and Silver after Subacute Intravenous Injection of Co-administered Gold and Silver Nanoparticles of similar sizes. Archives of Toxicology 2018:92(4);1393-1405 |
R835738C004 (2018) R835738C005 (2018) |
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| Journal Article | Weldon BA, Griffith WC, Workman T, Scoville DK, Kavanagh TJ, Faustman EM. 2018. In vitro to in vivo benchmark dose comparisons to inform risk assessment of quantum dot nanomaterials. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology 2018;10(4):e1507. |
R835738 (2017) R835738C001 (2018) R835738C004 (2017) R835738C004 (2018) R835738C005 (2017) R835738C005 (2018) |
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| Presentation | Faustman EM. Testicular cells co-culture as an alternative model for male reproductive toxicity. Presented workshop at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835738 (2016) R835738 (2017) R835738C002 (2017) R835738C004 (2017) |
not available |
| Presentation | Faustman EM, Smith MN. Neurodevelopmental disorders and disease & opportunities for new chemical testing data: understanding new tools from federal chemical testing programs. Presented to the California EPA via webinar, August 14, 2015. |
R834514 (2015) R834514 (Final) R835738 (2016) R835738 (2017) R835738C004 (2015) R835738C005 (2017) |
not available |
| Presentation | Faustman EM, Kavanagh TJ, Altemeier W, Kelly E, Griffith WC, Gao X, Van Ness K, Eaton DL. Predictive Toxicology Center for Organotypic Cultures and Assessment of AOPs for Engineered Nanomaterials. Poster presented at the Society of Toxicology 54th Annual Meeting and ToxExpo, San Diego, CA, March 22-26, 2015. |
R835738 (2016) R835738 (2017) R835738C002 (2017) R835738C004 (2017) R835738C005 (2017) |
not available |
| Presentation | Faustman EM, Kavanagh TJ. University of Washington Predictive Toxicology Center update. Presented at the Society of Toxicology 54th Annual Meeting and ToxExpo, San Diego, CA, March 22-26, 2015. |
R835738 (2016) R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
not available |
| Presentation | Faustman EM, Kavanagh TJ, Altemeier W, Kelly E, Griffith WC, Gao X, Van Ness K, Eaton DL. Organotypic Cultures and Assessment of AOPs for Engineered Nanomaterials: results from the University of Washington Predictive Toxicology Center (PTC). Poster presented at the Society of Toxicology Contemporary Concepts in Toxicology's FutureTox III: Bridges for Translation Conference, Arlington, VA, November 19-20, 2015. |
R835738 (2016) R835738 (2017) R835738C002 (2017) R835738C004 (2017) R835738C005 (2017) |
not available |
| Presentation | Faustman EM. Integrating in vitro studies for risk assessment of quantum dots:applications of dosimetry and benchmark evaluation methods. Presented at the 7th International Symposium on Nanotechnology, Occupational and Environmental Health (NanOEH 2015), University of Witwatersrand, Limpopo Province, South Africa, October 18-22, 2015. |
R835738 (2015) R835738 (2016) R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
not available |
| Presentation | Faustman EM. Integrating in vitro studies for risk assessment of quantum dots: applications of dosimetry and benchmark evaluation methods. Presented at the 7th International Symposium on Nanotechnology, Occupational and Environmental Health (NanOEH 2015), Limpopo Province, South Africa, October 19-22, 2015. |
R835738C004 (2017) R835738C005 (2015) R835738C005 (2017) |
not available |
| Presentation | Faustman EM. 3D testis culture: challenges and opportunities for informing AOP. Presented at a seminar in Seattle, WA, August 2016. |
R835738 (2016) R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
not available |
| Presentation | Faustman EM, Smith M. Prioritizing toxic chemicals in children’s consumer products. Presented via the Pediatric Environmental Health Specialty Units (PEHSU) National Classroom Grand Rounds Webinar, December 14, 2016. |
R835738 (2016) R835738 (2017) R835738C004 (2017) R835738C005 (2016) R835738C005 (2017) |
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| Presentation | Faustman EM. Virtual tissue modeling. Poster presented at the University of Washington’s Predictive Toxicology Center: Metal and Engineered Nanomaterials Quarterly Update, Seattle WA, February 2016. |
R835738 (2016) R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
not available |
| Presentation | Faustman EM. Framing our birth defects questions with systems biology: learning from our mentors. Presented at the 56th Annual Teratology Society Meeting, San Antonio, TX, June 26, 2016 (Josef Warkany lecture). |
R835738 (2016) R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
not available |
| Presentation | Faustman EM. Exposomes for children's studies: importance of life stage considerations. Presented at the NIEHS/EPA Children’s Centers Webinar Series: Exposome, Research Triangle Park, NC, May 11, 2016. |
R835738 (2016) R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
not available |
| Presentation | Faustman EM. Virtual tissue modeling. Poster presented at the University of Washington’s Predictive Toxicology Center: Metal and Engineered Nanomaterials Quarterly Update, Seattle WA, May 2016. |
R835738 (2016) R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
not available |
| Presentation | Faustman EM. Systems biology methods for translation of scientific findings across model platforms: identifying normal development versus chemical signals in complex systems. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) R835738C004 (2017) R835738C004 (2018) R835738C005 (2017) |
not available |
| Presentation | Faustman EM. Using systems biology for linking genes and environment for alcohol research. Presented at the Fetal Alcohol Spectrum Disorders Study Group Meeting, Denver, CO, June 24, 2017 (keynote speaker). |
R835738 (2017) R835738C002 (2017) R835738C004 (2018) |
not available |
| Presentation | Faustman EM. Integrating systems biology and public health to implement 3Rs–what have we learned and what do we need to do? Presented at the Institutional Animal Care and Use Committee (IACUC) Conference, New Orleans, LA, March 19-20, 2017 (keynote speaker). |
R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
not available |
| Presentation | Fitzpatrick SC. Incorporating in vitro reproductive and developmental assays into regulatory risk assessment. Presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835738 (2016) R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
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| Presentation | Klieforth B, Shaffer RM, Smith M, Faustman EM. Microphysiological system models and the Lautenberg Chemical Safety for the 21st Century Act. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) R835738C002 (2018) R835738C004 (2017) R835738C004 (2018) R835738C005 (2017) |
not available |
| Presentation | Lee, JH, Han JH, Kim JH, Kim BW, Bello D, Kim JK, Lee GH, Ahn K, Faustman EM, Park JD, Yu IJ. Exposure monitoring of graphene manufactureing workplace. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835738 (2016) R835738 (2017) R835738C004 (2017) |
not available |
| Presentation | Nicholas T, Haick A, Kavanagh TJ, Faustman E, Altemeier WA. Optimization of three-dimensional airway epithelium co-culture system as a platform for adverse outcome pathway assessment of engineered nanomaterials. Presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835738C001 (2017) R835738C004 (2017) |
not available |
| Presentation | Park S, Lee JH, Wilder C, Wegner S, Harris S, Hong S, Faustman EM. Organotypic modeling platform for identifying adverse response in testicular development. Poster presented at the University of Washington Undergraduate Research Symposium, Seattle, WA, May 2016. |
R835738 (2016) R835738 (2017) R835738C004 (2017) |
not available |
| Presentation | Shaffer RM, Welder CS, Ryu C, Yi HS, Park SY, Hong S, White CC, Workman T, Griffith WC, Faustman EM. Lifestage-specific organotypic modeling platform for adverse outcome pathways of male reproductive and developmental processes. Poster presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C004 (2017) R835738C004 (2018) R835738C005 (2017) |
not available |
| Presentation | Shaffer R, Wilder CS, Ryu C, Yi HS, Park SY, Hong S, White CC, Workman T, Griffith WC, Faustman EM. Lifestage-specific modeling platform for adverse outcome pathways of male reproductive and developmental processes. Poster presented at the Pacific Northwest Association of Toxicologists (PANWAT) Annual Meeting, Oregon State University, Corvallis, OR, September 29-30, 2016. |
R835738 (2016) R835738 (2017) R835738C002 (2017) R835738C004 (2017) R835738C005 (2017) |
not available |
| Presentation | Smith MN, Faustman EM, Grice J. Developing a toxicological framework for the interpretation of the Children's Safe Product Act data. Presented at the Northwest Environmental Health Conference, Portland, OR, April 17, 2015. |
R834514 (2015) R835738 (2016) R835738 (2017) R835738C004 (2017) |
not available |
| Presentation | Wilder CS, Wegner SH, Smith MN, Harris S, Hong SW, Griffith WC, Faustman EM. Organotypic modeling platform for adverse outcome pathways of male reproductive and developmental processes. Presented at the 56th Annual Meeting of the Teratology Society, San Antonio, TX, June 25-29, 2016. |
R835738 (2016) R835738 (2017) R835738C004 (2017) |
not available |
| Presentation | Wilder CS, Wegner SH, Organotypic modeling platform for adverse outcome pathways of male reproductive and developmental processes. Presented webinar at Virtual Tissues Meeting, Research Triangle Park, NC, May 2016. |
R835738 (2016) R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
not available |
| Presentation | Wilder C. Organotypic modeling platform for adverse outcome pathways of male reproductive and developmental processes. Presented at the University of Washington, Department of Environmental and Occupational Health Science Student Research Day, Seattle, WA, May 2016. |
R835738 (2016) R835738 (2017) R835738C004 (2017) |
not available |
| Presentation | Faustman EM, Kavanagh TJ., Altemeier W, Kelly E, Griffith WC, Gao X, Van Ness K, Eaton DL. Organotypic Cultures and Assessment of AOPs for Engineered Nanomaterials; Results from the University of Washington Predictive Toxicology Center (PTC). Poster presented at the Society of Toxicology Contemporary Concepts in Toxicology's FutureTox III: Bridges for Translation Conference, Arlington, VA, November19-20, 2015. |
R835738 (2017) R835738C004 (2017) R835738C005 (2017) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.